

About Us
The Hill Lab is housed in the Department of Biology at the University of York. We're also part of the York Structural Biology Laboratory and the York Biomedical Research Institute
Our Team
We're a group of friendly and supportive scientists interested in proteins, RNA, ribosomes, translational regulation and the control of virus gene expression. The Hill Lab is an inclusive, international space where diversity is celebrated.
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Principal Investigator
Chris H. Hill
Chris is a structural and molecular biologist with a background in X-ray crystallography, cryo-EM and RNA biology. He's interested in the regulation of viral gene expression - particularly in how RNA viruses 'break the rules' when they execute their own genetic code.

Postdoctoral Research Associate
Tim C. Passchier
Tim is originally from the Netherlands and joins us as a Wellcome-funded postdoctoral research associate with a broad background in structural and molecular virology gained at the Universities of Utrecht, Oxford, and Leeds. In the Hill lab he will be investigating virus-induced ribosomal recoding through structural and molecular approaches.

PhD student
Miguel Aracena Velázquez
Miguel is originally from Bolivia, but has lived most of his life abroad. He has a background in Biochemistry, and industry experience from his time at Oxford Nanopore Technologies. He is very excited to join the Hill Lab to begin his PhD project on investigating the structural and mechanistic basis of translation initiation in enteroviruses. Miguel is supported by the BBSRC White Rose Doctoral Training Partnership in Mechanistic Biology.

PhD student
Jemma Betts
Jemma has a background in structural and molecular protein biochemistry. After working at UCL studying the structures of infectious prions, Jemma is very excited to join the Hill lab and begin her PhD, investigating RNA-protein interactions that stimulate programmed ribosomal frameshifting during viral infection. She is enthusiastic to apply her experience with cryo-EM to her PhD project. Jemma is supported by the MRC DiMeN Doctoral Training Partnership.
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PhD student
Ella Warren
Ella has a background in protein biochemistry and structural biology, having worked on the poxviral DNA packaging machinery during her Masters degree at the University of York. Ella joined the Hill lab to investigate structural RNA elements in the foot-and-mouth disease virus genome, and the mechanistic basis of their contributions to viral replication. Ella is supported by funding from the Pirbright Institute, the Department of Biology at York, and the school of Physics, Engineering and Technology at York.

PhD student
Helena Dolan
Helena has a background in molecular biology and a longstanding fascination with RNA. Her interest began during a summer studentship at the University of Sussex investigating non-coding RNA, and was further developed through her work on the manufacturing of foot-and-mouth disease virus (FMDV) vaccines. She is excited to join the Hill Lab to explore how viral RNA structural elements influence programmed ribosomal frameshifting. Helena is supported by the BBSRC Yorkshire Bioscience Doctoral Training Partnership (YBDTP).

PhD student
James Law
James has a background in biophysical sciences and a deep fascination with the molecular mechanisms and behaviours underlying human diseases. Having previously worked on the molecular dynamics of Protein-DNA interactions responsible for biofilm stability (Master's degree, University of York), James is very excited to join the Hill Lab to investigate the structural and mechanistic behaviours of the large Cloverleaf and cre–3C–3CD complex, which govern enterovirus replication. James is supported by the MRC DiMeN Doctoral Training Partnership.

Visiting PhD student
Leon Walther
Leon joined us in 2025 as part of a new collaboration with Joana Faria's group in Biology at York. He earned his bachelor’s and master’s degrees at the University of Konstanz, Germany, with research experiences in New Zealand, CSSB Hamburg and EMBL Grenoble. There, he discovered his passion for neglected tropical diseases and now aims to use structural insights to advance drug discovery. He focuses on structurally and functionally characterizing key factors involved in monoallelic VSG expression in African trypanosomes.

Alumni

Summer Student
Ashleigh Smith
Ashleigh joined us for a summer project in 2022 through the Generation Research scheme. She now works for RSSL as a Biomolecular Analysis Senior Technician.

Research Technician
Catherine Cockeram
Cath joined us in 2022 as a founding member of the lab. With a background in genetics, microbiology and immunology, she's interested in studying processes used by pathogens to interact with and exploit host cells. Cath left our group in October 2024 to start a PhD with Dr Anton Calabrese at the University of Leeds.

Masters Student
Luke Corbett
Luke joined us for the 2023-2024 academic year as a 4th year Masters student. In collaboration with the McGonigal Group, he used X-ray crystallography and enzyme kinetics to investigate the protein-binding capacity of novel shapeshifting compounds.
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Summer Student
Alex Whitaker
Alex joined us in 2024 for a Generation Research summer project supervised by Miguel, investigating whether the EMCV 2A protein differentially affects host and virus mRNA translation. He previously worked at The Pirbright Institute applying CRISPR/Cas9 to attempt to improve vaccines against Marek's Disease Virus. Alex is now in the final year of his Masters degree.

Visiting Associate
Karla Helena Bueno
Karla joined us in 2022/23 as part of a collaboration with Sergey Melnikov's group. Originally from the Dominican Republic, Karla has a background in microbiology from her studies at Michigan State University. She earned her PhD from Newcastle University, where she investigates the molecular mechanisms of ribosome hibernation in bacteria.

Visiting Associate
Lewis Chan
Lewis joined us in 2024/5 to work on ribosomes in collaboration with Sergey Melnikov's group at the University of Newcastle. He uses cryo-electron microscopy to understand how various bacteria preserve their vital machinery such as ribosomes during conditions of stress.

MSc student
Jiaxin Zhuo
Jiaxin joined us in 2023/24 as part of a collaborative project with Pegine Walrad to work on Leishmania mexicana ribosomes. Jia performed ribosome isolation, immunoprecipitation, polysome profiling, and mass spectrometry data analysis. Jia is now an NHS Assistant Healthcare Scientist.
Our Facilities
We benefit from direct access to state-of-the art core equipment in the Biosciences Technology Facility and the adjacent Eleanor and Guy Dodson Building in the York Structural Biology Laboratory
Our Funding










