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About Us

The Hill Lab is housed in the Department of Biology at the University of York. We're also part of the York Structural Biology Laboratory and the York Biomedical Research Institute

Our Team

We're a group of friendly and supportive scientists interested in proteins, RNA, ribosomes, translational regulation and the control of virus gene expression. The Hill Lab is an inclusive, international space where diversity is celebrated. 

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Principal Investigator

Chris H. Hill

Chris is a structural and molecular biologist with a background in X-ray crystallography, cryo-EM and RNA biology. He's interested in the regulation of viral gene expression -  particularly in how RNA viruses 'break the rules' when they execute their own genetic code. 

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Postdoctoral Research Associate

Tim C. Passchier

Tim is originally from the Netherlands and joins us as a Wellcome-funded postdoctoral research associate with a broad background in structural and molecular virology gained at the Universities of Utrecht, Oxford, and Leeds. In the Hill lab he will be investigating virus-induced ribosomal recoding through structural and molecular approaches.

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PhD student

Miguel Aracena Velázquez

Miguel is originally from Bolivia, but has lived most of his life abroad. He has a background in Biochemistry, and industry experience from his time at Oxford Nanopore Technologies. He is very excited to join the Hill Lab to begin his PhD project on investigating the structural and mechanistic basis of translation initiation in enteroviruses. Miguel is supported by the BBSRC White Rose Doctoral Training Partnership in Mechanistic Biology.  

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PhD student

Jemma Betts

Jemma has a background in structural and molecular protein biochemistry. After working at UCL studying the structures of infectious prions, Jemma is very excited to join the Hill lab and begin her PhD, investigating RNA-protein interactions that stimulate programmed ribosomal frameshifting during viral infection. She is enthusiastic to apply her experience with cryo-EM to her PhD project. Jemma is supported by the MRC DiMeN Doctoral Training Partnership.  

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PhD student

Ella Warren

Ella has a background in protein biochemistry and structural biology, having worked on the poxviral DNA packaging machinery during her Masters degree at the University of York. Ella joined the Hill lab to investigate structural RNA elements in the foot-and-mouth disease virus genome, and the mechanistic basis of their contributions to viral replication. Ella is supported by funding from the Pirbright Institute, the Department of Biology at York, and the school of Physics, Engineering and Technology at York. 

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PhD student

Helena Dolan

Helena has a background in molecular biology and a longstanding fascination with RNA. Her interest began during a summer studentship at the University of Sussex investigating non-coding RNA, and was further developed through her work on the manufacturing of foot-and-mouth disease virus (FMDV) vaccines. She is excited to join the Hill Lab to explore how viral RNA structural elements influence programmed ribosomal frameshifting. Helena is supported by the BBSRC Yorkshire Bioscience Doctoral Training Partnership (YBDTP).

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PhD student

James Law

James has a background in biophysical sciences and a deep fascination with the molecular mechanisms and behaviours underlying human diseases. Having previously worked on the molecular dynamics of Protein-DNA interactions responsible for biofilm stability (Master's degree, University of York), James is very excited to join the Hill Lab to investigate the structural and mechanistic behaviours of the large Cloverleaf and cre–3C–3CD complex, which govern enterovirus replication. James is supported by the MRC DiMeN Doctoral Training Partnership.  

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    Visiting PhD student

    Leon Walther

    Leon joined us in 2025 as part of a new collaboration with Joana Faria's group in Biology at York. He earned his bachelor’s and master’s degrees at the University of Konstanz, Germany, with research experiences in New Zealand, CSSB Hamburg and EMBL Grenoble. There, he discovered his passion for neglected tropical diseases and now aims to use structural insights to advance drug discovery. He focuses on structurally and functionally characterizing key factors involved in monoallelic VSG expression in African trypanosomes.

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    Alumni

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    Summer Student

    Ashleigh Smith

    Ashleigh joined us for a summer project in 2022 through the Generation Research scheme. She now works for RSSL as a Biomolecular Analysis Senior Technician. 

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    Visiting PhD Student

    Conor Fairhead

    Conor joined us in 2022 to do some X-ray crystallography. He is now continuing with his PhD at the Department of Pathology, University of Cambridge.

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    Research Technician 

    Catherine Cockeram

    Cath joined us in 2022 as a founding member of the lab. With a background in genetics, microbiology and immunology, she's interested in studying  processes used by pathogens to interact with and exploit host cells. Cath left our group in October 2024 to start a PhD with Dr Anton Calabrese at the University of Leeds. 

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    Masters Student

    Luke Corbett

    Luke joined us for the 2023-2024 academic year as a 4th year Masters student. In collaboration with the McGonigal Group, he used X-ray crystallography and enzyme kinetics to investigate the protein-binding capacity of novel shapeshifting compounds.

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      Summer Student

      Alex Whitaker

      Alex joined us in 2024 for a Generation Research summer project supervised by Miguel, investigating whether the EMCV 2A protein differentially affects host and virus mRNA translation. He previously worked at The Pirbright Institute applying CRISPR/Cas9 to attempt to improve vaccines against Marek's Disease Virus. Alex is now in the final year of his Masters degree. 

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        Visiting Associate 

        Karla Helena Bueno 

        Karla joined us in 2022/23 as part of a collaboration with Sergey Melnikov's group. Originally from the Dominican Republic, Karla has a background in microbiology from her studies at Michigan State University. She earned her PhD from Newcastle University, where she investigates the molecular mechanisms of ribosome hibernation in bacteria.

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        Visiting Associate 

        Lewis Chan

        Lewis joined us in 2024/5 to work on ribosomes in collaboration with Sergey Melnikov's group at the University of Newcastle. He uses cryo-electron microscopy to understand how various bacteria preserve their vital machinery such as ribosomes during conditions of stress.

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        MSc student

        Jiaxin Zhuo

        Jiaxin joined us in 2023/24 as part of a collaborative project with Pegine Walrad to work on Leishmania mexicana ribosomes. Jia performed ribosome isolation, immunoprecipitation, polysome profiling, and mass spectrometry data analysis. Jia is now an NHS Assistant Healthcare Scientist.

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        Our Facilities

        We benefit from direct access to state-of-the art core equipment in the Biosciences Technology Facility and the adjacent Eleanor and Guy Dodson Building in the York Structural Biology Laboratory

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        Cryo-EM

        • 2x FEI Vitrobot

        • Glow discharger, plasma cleaner and carbon evaporator 

        • 200 kV Glacios with Falcon IV and Selectris energy filter

        • Viking2 compute cluster:   12,864 CPU cores and 60 GPUs

        • Frequent access to Krios at Leeds and eBIC

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        X-ray crystallography

        • Mosquito and Oryx robots

        • Automated crystal plate imaging robot

        • Rigaku XtaLAB Synergy-R diffractometer

        • Automatic cryo sample changer

        • Frequent access to Diamond Light Source through BAG

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        Imaging and cytometry

        • Zeiss Elyra 7 with SIM2

        • Zeiss LSM 880 with Airyscan

        • Zeiss LSM 780 multiphoton

        • Zeiss LSM 710

        • Zeiss LSM 510 META

        • Four-colour custom TIRF imaging

        • LUMICKS C-Trap optical tweezers

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        Molecular interactions

        • LUMICKS C-Trap optical tweezers

        • smFRET confocal (EI-FLEX)

        • Mass photometry (Refeyn)

        • Isothermal Titration Calorimetry

        • Surface Plasmon Resonance

        • SEC-MALS

        • Microscale Thermophoresis

        • Differential Scanning Fluorimetry

        • Circular Dichroism Spectroscopy

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        Protein and RNA purification

        • ÄKTA Pure FPLC with triple wavelength detector, multi-inlet, and sample loading pump

        • ÄKTA Go FPLC

        • Sucrose gradient maker 

        • E.coli, baculovirus and mammalian expression  

        Our Funding

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        © 2026 Chris H. Hill

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