Our Publications

Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex

Butt BG, Owen DJ, Jeffries CM, Ivanova L, Hill CH, Houghton JW, Ahmed MF, Antrobus R, Svergun DI, Welch

JJ, Crump CM, Graham SC

eLife (2020) May 11;9:e53789. doi: 10.7554/eLife.5378

https://pubmed.ncbi.nlm.nih.gov/32391791/

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Structure of the Fanconi anaemia monoubiquitin ligase complex

Shakeel S†, Rajendra E†, Alcón P, O’Reilly F, Chorey D, Maslen S, Degliesposti G, Russo CJ, He S, Hill CH, Skehel M, Scheres S, Patel K, Rappsilber J, Robinson C, Passmore LA.

Nature (2019) Nov;575(7781):234-237. doi: 10.1038/s41586-019-1703-4​

https://pubmed.ncbi.nlm.nih.gov/32391791/

Spotlight article in Trends in Biochemical Sciences: ‘FANally…A Structure Emerges of the Fanconi Anemia Core Complex’

Featured in MRC LMB Insight on Research: 'Decade-long collaboration results in the first structure of the Fanconi anaemia core complex'

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Characterisation of the stimulators of protein-directed ribosomal frameshifting in Theiler’s murine encephalomyelitis virus

Napthine S, Bell S, Hill CH, Brierley I†, Firth AE†

Nucleic Acids Research (2019) Sep 5;47(15):8207-8223. doi: 10.1093/nar/gkz503

https://pubmed.ncbi.nlm.nih.gov/31180502/

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The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases

Tang TTL, Stowell JAW, Hill CH, Passmore LA.

Nature Structural & Molecular Biology (2019) Jun;26(6):433-442. doi: 10.1038/s41594-019-0227-9​

https://pubmed.ncbi.nlm.nih.gov/31110294/

Recommended by F1000: https://f1000.com/prime/735791923

Featured in MRC LMB Insight on Research: 'A novel mode of RNA recognition based on structure not sequence'

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Activation of the endonuclease that defines mRNA 3ʹ-ends requires incorporation into an 8-subunit core cleavage and polyadenylation factor complex

Hill CH, Borekaite V, Kumar A, Casañal A, Kubik P, Degliesposti G, Maslen S, Mariani A, von Loeffelholz O, Girbig M, Skehel M, Passmore LA.

Molecular Cell (2019) Mar 21;73(6):1217-1231.e11. doi: 10.1016/j.molcel.2018.12.023

​​https://pubmed.ncbi.nlm.nih.gov/30737185/

Featured on Instruct-ERIC news: ‘How to generate the end of an mRNA’

Recommended by F1000:  https://f1000.com/prime/735057887

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A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding

Stowell JAW, Wagstaff JL, , Yu M, McLaughlin SH, Freund SMV, Passmore LA.

Journal of Biological Chemistry (2018) Jun 15;293(24):9210-9222. doi: 10.1074/jbc.RA118.002291

https://pubmed.ncbi.nlm.nih.gov/29695507/

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The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure

Hill CH, Cook GM, Spratley SJ, Fawke S, Graham SC, Deane JE.

Nature Communications (2018) 11;9(1):151. doi: 10.1038/s41467-017-02361-y

https://pubmed.ncbi.nlm.nih.gov/29323104/

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Architecture of eukaryotic mRNA 3’-end processing machinery

Casañal A†, Kumar A†, Hill CH, Easter AD, Emsley P, Degliesposti G, Gordiyenko Y, Santhanam B, Wolf J, Wiederhold K, Dornan GL, Skehel M, Robinson CV, Passmore LA.

Science (2017) Nov 24;358(6366):1056-1059. doi: 10.1126/science.aao6535​

https://pubmed.ncbi.nlm.nih.gov/29074584/

Featured in MRC LMB Insight on Research: ‘How the poly(A) tail is added to the end of mRNAs’
Featured in Diamond Light Source News: ‘Tall tails of mRNA’

Featured in Drug Target Review: 'Cryo-electron microscopy used to identify CPF protein structure’

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Insights into Hunter Syndrome from the structure of iduronate-2-sulfatase 

Demydchuk M†, Hill CH, Zhou A, Stein PE, Marchesan D, Terwilliger TC, Deane JE, Read RJ.

Nature Communications (2017) Jun 8:8:15786. doi: 10.1038/ncomms15786

https://pubmed.ncbi.nlm.nih.gov/28593992/

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Molecular mechanisms of disease pathogenesis differ in Krabbe disease variants

Spratley SJ, Hill CH, Viuff AH, Edgar JR, Skjødt K, Deane JE.

Traffic (2016) Aug;17(8):908-22. doi: 10.1111/tra.12404

https://pubmed.ncbi.nlm.nih.gov/27126738/

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Azasugar inhibitors as pharmacological chaperones for Krabbe disease

Hill CH†, Viuff AH†, Spratley SJ, Salamone S, Christensen SH, Read RJ, Moriarty NW, Jensen HH, Deane JE.

Chemical Science (2015) May 20;6(5):3075-3086. doi: 10.1039/c5sc00754b

https://pubmed.ncbi.nlm.nih.gov/26029356/

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Structural snapshots illustrate the catalytic cycle of β-galactocerebrosidase, the defective enzyme in Krabbe disease               

Hill CH, Graham SC, Read RJ, Deane JE.

Proceedings of the National Academy of Sciences USA (2013) Dec 17;110(51):20479-84. doi: 10.1073/pnas.1311990110

https://pubmed.ncbi.nlm.nih.gov/24297913/

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Structure of human saposin A at lysosomal pH          

Hill CH, Read RJ, Deane JE.

Acta Crystallogr F Struct Biol Commun. (2015) Jul;71(7):895-900. doi: 10.1107/S2053230X15008584

https://pubmed.ncbi.nlm.nih.gov/26144235/

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A novel membrane protein, VanJ, conferring resistance to teicoplanin

Novotna G, Hill CH, Vincent K, Liu C, Hong HJ.

Antimicrobial Agents & Chemotherapy (2012) Apr;56(4):1784-96. doi: 10.1128/AAC.05869-11

https://pubmed.ncbi.nlm.nih.gov/22232274/

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Genome-wide dynamics of a bacterial response to antibiotics that target the cell envelope

Hesketh A, Hill CH, Mokhtar J, Novotna G, Tran N, Bibb M, Hong HJ.

BMC Genomics (2011) May 11:12:226. doi: 10.1186/1471-2164-12-226

https://pubmed.ncbi.nlm.nih.gov/21569315/

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