top of page
Dr Chris Hill_332.jpg


Dr Chris H. Hill

Principal Investigator and Lecturer

Wellcome & Royal Society Sir Henry Dale Fellow

+44 (0)1904 328688

York Structural Biology Laboratory 

York Biomedical Research Institute 

Department of Biology (B/L/021)

University of York

Wentworth Way

York, YO10 5DD


Chris did his PhD in the laboratories of Dr Janet Deane and Prof. Randy Read at the CIMR, studying the structure and mechanism of lysosomal hydrolase enzymes. In 2015, he joined the Lori Passmore's group at the MRC-LMB as a Career Development Fellow to work on the pre-mRNA cleavage and polyadenylation machinery. Chris then moved to the Department of Pathology at the University of Cambridge in 2018 to direct a programme of work for Prof. Ian Brierley on ribosomal frameshifting. In 2021, he was awarded a Sir Henry Dale Fellowship from the Wellcome Trust and Royal Society to establish his own research group at the University of York.

Chris also loves teaching. He is a former Fellow and College Lecturer in Natural Sciences at Queens’ College, Cambridge with more than ten years experience in delivering undergraduate tutorials.

When he's not doing science, Chris enjoys writing music for piano:

  • YouTube
  • Spotify
  • Amazon
  • iTunes
  • music


October 2021

November 2017 - August 2021

Research Associate

Department of Pathology, University of Cambridge

August 2015 - October 2017

Postdoctoral Scientist

MRC Laboratory of Molecular Biology

October 2010 - July 2015

PhD student

Wellcome Infection & Immunity programme, CIMR

Wellcome Sir Henry Dale Fellow and Lecturer appointment at University of York. Lab opens! 

Second postdoc in the Brierley Laboratory, working on mechanisms of frameshifting in cardioviruses.  Solved crystal structures of viral 2A proteins, revealing a new RNA-binding fold. Elucidated the RNA binding mechanism and determined cryo-EM structures of 2A bound to initiated ribosomes. 

First postdoc in the Passmore Laboratory, working on structure and mechanism of the cleavage and polyadenylation factor (CPF). Created a recombinant minimal machinery (13 proteins) that faithfully reproduced  specific pre-mRNA cleavage and polyadenylation in vitro. Determined structures of the nuclease sub-complex by cryo-EM and X-ray crystallography.

PhD with Dr Janet Deane and Prof. Randy Read, working on glycolipid degradation by lysosomal hydrolase enzymes. Used diffusion trapping to visualise the GALC catalytic cycle, explored the utility of azasugars as chemical chaperones and solved the crystal structure of a GALC-SapA-detergent complex, revealing likely mechanisms of lipid presentation.

bottom of page